A-ACT
|
Alpha-1 antichymotrypsin, A-ACT, ACT, A1AT
|
α1-Antichymotrypsin; histiocytes; pancreatic pseudopapillary tumor
|
A-AT
|
Alpha-1-antitrypsin, A-AT
|
α1-Antitrypsin; inherited A-AT deficiency
|
ACTH
|
Adrenocorticotropic hormone
|
Antiadrenocorticotropic hormone; anterior pituitary
|
Actin−Muscle-specific
|
Muscle-specific actin, MSA, HHF-35
|
Skeletal, smooth, and cardiac muscle; myofibroblastic differentiation
|
Actin−Smooth Muscle (SMA)
|
Smooth muscle actin
|
Myofibroblasts; myoepithelial cells
|
AE1
|
Cytokeratin AE1
|
Cytokeratin AE1; epithelial marker
|
AE1/AE3
|
Cytokeratin AE1/AE3
|
Screening cytokeratin cocktail; epithelial marker
|
AE3
|
Cytokeratin AE3
|
Cytokeratin AE3; high molecular weight cytokeratin; epithelial marker
|
AFP
|
Alpha fetoprotein
|
α-Fetoprotein (AFP); hepatocellular carcinoma; hepatoid carcinoma; yolk sac tumor
|
AKT Phosphate
|
RUO AKT 1; protein kinase B, PKB, Rac-alpha
|
AKT (protein kinase B)
|
ALK-1
|
Anaplastic lymphoma kinase-1
|
Anaplastic lymphoma kinase-1; anaplastic large-cell lymphoma; inflammatory myofibroblastic tumor; adenocarcinoma of lung subset
|
Amyloid A
|
|
Amyloid A protein
|
Androgen Receptor
|
AR
|
Prostate carcinoma; associated with prognosis and treatment outcome
|
Annexin A1
|
Annexin A, Annexin 1, ANXA1
|
Hairy cell leukemia; myeloid cells
|
B72.3
|
TAG72, Breast-3,BRST-3
|
Simple epithelium; adenocarcinoma; excludes mesothelioma
|
BCA-225
|
Breast carcinoma-associated glycoprotein
|
Breast carcinoma-associated glycoprotein; breast carcinoma and other adenocarcinomas
|
BCL-1 (Cyclin D1)
|
Cyclin D1; PRAD-1
|
Mantle-cell lymphoma; multiple myeloma subset
|
BCL-1/CD20
|
|
Double stain; useful for the diagnosis of mantle cell lymphoma
|
BCL-2
|
|
Follicular lymphoma; other B-cell and T-cell lymphomas; soft tissue tumor
|
BCL-2/BCL-6
|
|
Double stain; useful for the diagnosis of follicular center cell lymphoma, diffuse large-cell type
|
BCL-6
|
|
Follicular center B-cells; follicular lymphoma; DLBCL subset
|
Ber-EP4
|
BER-EP4, BerEP4, BEREP4, Ep-Cam, epithelial antigen, CD326, Ep-CAM
|
Epithelial antigen; carcinoma; differentiates carcinoma from mesothelioma
|
β-Amyloid
|
Amyloid beta-protein (A-beta-P); amyloid beta-peptide; A-beta; beta-A4 protein; beta-protein
|
Alzheimer's disease; senile plaques; neurofibrillary tangles; cerebrovascular deposits
|
β-Catenin
|
beta-catenin
|
Soft tissue lesion; fibromatosis; synovial sarcoma
|
BG8 (LewisY)
|
Blood group-related antigen; Lewis Y
|
Adenocarcinoma; exclude mesothelioma
|
BOB-1
|
BOB.1/OBF.1
|
B-cells
|
CA 19.9
|
CA-19.9
|
Pancreas, GI, ovary, lung, and transitional cell carcinoma
|
CA 125 (OC125)
|
OC125, ovarian cancer antigen
|
Female genital tract; breast carcinoma; other adenocarcinoma, including lung and pancreatobiliary
|
CAIX
|
Carbonic anhydrase IX, CA9
|
Carbonic anhydrase IX; renal cell carcinoma (RCC); distinguish clear cell renal cell carcinoma from other RCC subset
|
Calcitonin
|
|
Thyroid C-cells; medullary carcinoma
|
Caldesmon
|
CALD, h-Caldesmon
|
Smooth muscle and myoepithelial cells
|
Calponin
|
CALP
|
Myoepithelial, myofibroblastic, and smooth muscle cells
|
Calretinin
|
CALRET
|
Mesothelial cells; sex cord stromal tumor; adrenal cortical tumor
|
CAM 5.2
|
CK8/18
|
Low molecular weight cytokeratin 8 and 18; epithelial tumor
|
CAM 5.2/AE1
|
|
Screening cytokeratin cocktail; epithelial tumor
|
CD1a
|
|
Cortical thymocytes; Langerhans cell histiocytosis (LCH); T-ALL subset
|
CD2
|
E-rosette receptor; LFA-2
|
Pan, thymic, and peripheral T-cells; NK cells; neoplastic mast cells
|
CD3 (M)
|
CD3 (mono)
|
CD3 (monoclonal); pan T-cells
|
CD3 (P)
|
CD3 (poly)
|
CD3 (polyclonal); pan T-cells
|
CD3/CD20
|
|
Double stain; useful to distinguish B-cells (CD20+) and T-cells (CD3+)
|
CD4
|
|
Helper/inducer T-cells; thymocyte and monocyte subsets
|
CD5
|
|
Pan T-cells; B-cell lymphoma subset (B-CLL/SLL and MCL); thymic carcinoma
|
CD7
|
|
Pan T‐cells; NK cells, thymocytes; rare AML
|
CD8
|
|
Suppressor/cytotoxic T‐cells; thymocyte and T‐cell/NK cell subsets; T‐LGL leukemia
|
CD10
|
CALLA
|
CALLA; B-cell and T-cell lymphoma subsets; endometrial stromal cells; renal cell carcinoma subset
|
CD14
|
|
Mature monocytes; some granulocytes; macrophages
|
CD15
|
LeuM1
|
Epithelial, myeloid, and Reed-Sternberg cells; Hodgkin lymphoma
|
CD20
|
L26
|
Pan B-cells
|
CD21
|
|
Follicular dendritic cells; B-cell subset
|
CD22
|
|
Pan B-cells
|
CD23
|
BU38, SP23
|
Follicular dendritic cells; B-cell subset; B-CLL
|
CD25
|
|
Activated T‐ and B‐cells; HCL; ATLL
|
CD30
|
Ki-1, BerH2
|
Reed‐Sternberg cells; anaplastic large‐cell lymphoma; DLBCL subset; Hodgkin lymphoma; embryonal carcinoma
|
CD31
|
PECAM, platelet-endothelial cell adhesion molecule-1
|
Endothelium; vascular neoplasm; plasma cells
|
CD33
|
|
Monocytes; myeloid cells; AML; ALL subset
|
CD34
|
Clones: QBEnd/10 and HPCA
|
Blasts; stem cells; endothelium; GIST; soft tissue tumor subset
|
CD35
|
Follicular dendritic cell marker; CR1
|
Follicular dendritic cells
|
CD43
|
MT1 (T-cell)
|
T-cells; B-cell lymphoma subset (B-CLL/SLL, MCL, Burkitt); plasma and myeloid cells; histiocytes
|
CD45 (LCA)
|
LCA, leukocyte-common antigen
|
Leukocyte common antigen
|
CD45RA
|
CD45RA (B-cell marker)
|
B-cells
|
CD45RO
|
CD45RO (T-cell marker), UCHL-1
|
Activated/memory T-cells; B-cell subset
|
CD56
|
N-CAM, LEU-6
|
Neural and neuroendocrine tumor; soft tissue tumor subset; NK cells; plasma and T-cell subsets; LGL leukemia
|
CD57
|
HNK‐1, LEU‐7
|
Neural and neuroendocrine tumor; thymoma; NK cells; T-LGL leukemia; T-cell subset
|
CD61
|
GPIIIA
|
Megakaryocytes; platelets
|
CD68
|
KP-1
|
Histiocytes; macrophages
|
CD71
|
|
Erythroid precursors and large-cell lymphoma; transferrin receptor; activated T- and B-cells; macrophages
|
CD74
|
|
B-cells
|
CD79a
|
|
Pan B-cells
|
CD99
|
MIC2, O13
|
PNET/Ewing sarcoma; soft tissue tumor subset; sex cord stromal tumor
|
CD117 (c-KIT)
|
CD117, c-KIT
|
GIST; subset of carcinoma including adenoid cystic carcinoma; germ cell neoplasm; hematolymphoid neoplasm
|
CD123
|
|
Dendritic cell precursors; type 2 (DC2) cells; blastic plasmacytoid dendritic cell neoplasm (BPDCN)
|
CD138
|
Syndecan-1
|
Plasma cells; subset of epithelial cells
|
CD163
|
M130, Ber-Mac3, Ki-M8, SM4
|
Monocytes; macrophages; dendritic interstitial cells
|
CDX-2
|
|
Enteric differentiation; GI tumor; colorectal carcinoma; carcinoid tumor subset
|
CDX-2/CK-7
|
|
Double stain; useful to distinguish stomach and colon carcinoma from breast, lung, and ovarian carcinoma
|
CEA (M)
|
Carcinoembryonic antigen (mono)
|
Carcinoembryonic antigen (monoclonal); adenocarcinoma
|
CEA (P)
|
Carcinoembryonic antigen (poly)
|
Carcinoembryonic antigen (polyclonal); epithelial marker; adenocarcinoma subset; negative in mesothelioma
|
Chromogranin A
|
CHROM
|
Neuroendocrine neoplasm; paraganglioma
|
Chymotrypsin
|
|
Exocrine pancreas; acinar cell tumor
|
CK-5
|
Cytokeratin 5
|
Tumor with squamous differentiation; squamous cell vs adenocarcinoma of lung classification; myoepithelial cells; benign vs malignant breast intraductal proliferation
|
CK-5/6
|
Cytokeratin 5/6
|
Tumor with squamous differentiation; squamous cell vs adenocarcinoma of lung classification; myoepithelial cells; benign vs malignant breast intraductal proliferation
|
CK-7
|
Cytokeratin 7
|
Various subtypes of carcinoma; frequently used in conjunction with CK-20 for tumor profiling
|
CK-7/TTF-1
|
|
Double stain; useful for the diagnosis of lung adenocarcinoma
|
CK-14
|
Cytokeratin 14
|
High molecular weight cytokeratin; tumor with squamous differentiation; myoepithelial cells; breast carcinoma with basal-like phenotype
|
CK-17
|
Cytokeratin 17
|
High molecular weight cytokeratin; tumor with squamous differentiation; pancreatobiliary adenocarcinoma; breast carcinoma with basal-like phenotype
|
CK-18
|
Cytokeratin 18
|
Low molecular weight cytokeratin
|
CK-19
|
Cytokeratin 19
|
Epithelial tumor; papillary carcinoma of the thyroid vs benign thyroid lesion
|
CK-20
|
Cytokeratin 20
|
Subset of carcinoma; reacts primarily with gastric and intestinal epithelium, urothelium, and Merkel cells
|
CK-HMW (34βE12)
|
Cytokeratin−high molecular weight, keratin 903, CK903, CK34bE12, 34betaE12
|
CK-903; broad-spectrum high molecular weight cytokeratin; squamous cell and subsets of adenocarcinoma and transitional cell carcinoma; prostate basal cells; prostate carcinoma vs adenosis/PIN
|
CK-LMW (35βH11)
|
Cytokeratin−low molecular weight, CK35bH11, CK8, 35betaH11
|
CK-8; epithelial neoplasm with simple epithelium
|
CMV−IHC
|
Cytomegalovirus by IHC
|
Cytomegalovirus
|
COLL-IV
|
Collagen IV
|
Collagen type IV; basement membrane material; soft tissue tumor subset
|
COX-2
|
Cyclooxygenase-2
|
Cyclooxygenase-2; prognostic and predictive marker in a variety of tumors
|
D2-40
|
Podoplanin
|
Evaluation of lymphatic endothelial differentiation for lymphatic invasion; subset of angiosarcoma; vascular tumor of lymphatic origin; mesothelioma
|
DBA44 (HCL)
|
DBA.44, HCL
|
Hairy cell leukemia
|
Desmin
|
DES
|
Striated and smooth muscle; leiomyosarcoma; rhabdomyosarcoma; desmoplastic small round cell tumor
|
DOG1
|
|
GIST, in particular CD117-negative lesion
|
EBER−ISH
|
EBV by ISH; Epstein-Barr virus
|
Epstein-Barr early RNA; Epstein-Barr virus identification
|
EBV (LMP1)
|
Epstein-Barr virus
|
Epstein-Barr virus; latent membrane protein
|
E-Cadherin
|
E-CAD
|
Ductal vs lobular lesion of breast; positive in ductal lesion and negative in lobular neoplasia
|
EMA
|
Epithelial membrane antigen, MAM6, MFGMP
|
Epithelial membrane antigen; epithelial marker; subset of sarcoma, meningioma, and hematolymphoid neoplasm
|
ER
|
Estrogen receptor
|
Estrogen receptor; predictive of endocrine therapy response in breast carcinoma; lower female genital tract carcinoma; endometrial stromal neoplasm; soft tissue lesion subset
|
ERCC1
|
Excision repair cross-complementation group 1
|
Excision repair cross-complementation group 1; lung carcinoma; predictive indicator for cisplatin therapy
|
Factor VIII (vWF)
|
Von Willebrand factor, vWF
|
Von Willebrand factor; endothelial marker; vascular neoplasm; blast cells in acute megakaryocytic leukemia
|
Factor XIIIa
|
Factor XIII, F13a
|
Dermal dendrocytes and dendritic interstitial cells; used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans; fibrohistiocytic neoplasm
|
Fascin
|
|
Hodgkin and Reed-Sternberg cells
|
FLI-1
|
|
Endothelial vascular cells/tumor; Ewing sarcoma/PNET; lymphoblastic lymphoma/leukemia
|
FSH
|
Follicle stimulating hormone
|
Follicular-stimulating hormone; anterior pituitary
|
Galectin-3
|
GAL3
|
Benign vs malignant thyroid follicular neoplasm, in particular papillary carcinoma
|
Gastrin
|
|
Gastric carcinoid; pancreatic endocrine neoplasm subset
|
GCDFP-15
|
Gross cystic disease fluid protein 15, BRST-2
|
Gross cystic disease fluid protein-15; breast carcinoma; salivary and sweat gland neoplasm
|
GFAP
|
Glial fibrillary acidic protein
|
Glial fibrillary acidic protein; glioma; lesion with glial differentiation; salivary gland tumor; neural neoplasm subset
|
Glucagon
|
GLU
|
Pancreatic endocrine neoplasm
|
Glycophorin A
|
GPH-A
|
Erythroid cells
|
Glypican-3
|
GPC3
|
Hepatocellular carcinoma; germ cell tumor; yolk sac tumor
|
Granzyme B
|
|
Cytotoxic T-cell subset; NK cells
|
Growth Hormone (GH)
|
GH, hGH
|
Growth hormone; anterior pituitary
|
GST
|
Glutathione S-transferase p, GST pi, GST P1
|
Distinguish Hodgkin disease and histiocytic malignancy from T-cell lymphoma
|
HAM 56
|
HAM 56, anti-macrophage, macrophage
|
Histiocytes
|
HBME-1
|
Human mesothelial cell
|
Mesothelial cells; subset of adenocarcinoma, in particular lower female genital tract origin; papillary carcinoma of the thyroid
|
HBP (H. pylori)
|
Helicobacter pylori, H. pylori, HBP
|
Helicobacter pylori
|
HCAg
|
Hepatitis C antigen
|
Hepatitis C antigen
|
HCG
|
Beta-HCG, B-HCG, human chorionic gonadotropin
|
Human chorionic gonadotropin (beta); germ cell tumor; trophoblastic disease
|
Hemoglobin A
|
HgB A, HEMGL AF
|
Red cell precursors
|
HEP B CORE (HBcAg)
|
Hepatitis B core antigen, HBVc, HBcAg
|
Hepatitis B core antigen; hepatitis B
|
HEP B SURF (HBsAg)
|
Hepatitis B surface antigen, HBVs, HBsAg
|
Hepatitis B surface antigen; hepatitis B
|
HepPar 1
|
Hepatocyte
|
Hepatocellular carcinoma; hepatoid tumor; germ cell tumor
|
HER2
|
HER2/neu, c-erb2, Herceptest
|
HER-2 protein overexpression; FDA-approved test for detection of HER2/neu; prognostic and predictive indicator in breast carcinoma
|
Herpes I
|
Herpes simplex virus 1 antigen, HSV-1
|
Herpes simplex virus type I
|
Herpes II
|
Herpes simplex virus II antigen, HSV-II
|
Herpes simplex virus type II
|
HHV-8
|
Human herpesvirus, type 8, HHV8 latent nuclear antigen, LNA
|
Human herpesvirus 8; Kaposi’s sarcoma; primary effusion lymphoma
|
HLA-DR
|
HLA-DR
|
Human leukocyte antigen; MHC class II antigen; B-cells; monocytes; myeloid cells; AML; ALL
|
HMB-45
|
Melanosome
|
Melanoma-associated marker; melanocytic lesion; pecoma
|
HPL
|
Human placental lactogen, human chorionic somatomammotropin
|
Human placental lactogen; intermediate trophoblasts; placental site trophoblastic lesion
|
HPV−IHC
|
Human papilloma virus antigen, papillomavirus, HPV IHC
|
Human papilloma virus
|
HPV (6/11)−ISH
|
Human papilloma virus
|
Low-risk human papilloma virus subtypes
|
HPV (16/18)−ISH
|
Human papilloma virus
|
High-risk human papilloma virus subtypes
|
HPV (31/33)−ISH
|
Human papilloma virus
|
High-risk human papilloma virus subtypes
|
HPV WSS−ISH
|
Human papilloma virus
|
Human papilloma virus wide screen; subtypes (6, 11, 16, 18, 30, 31, 33, 35, 45, 51, 52)
|
HPV High−ISH
|
Human papilloma virus, high risk by ISH, HPV III, HPV HR (16/18)
|
Human papilloma virus probe cocktail; subtypes (16, 18, 31, 33, 35, 45, 51, 52, 56, 58, 59, 68, 70); types 16 and 18 are associated with cervical, vaginal, and vulvar malignancies
|
HPV Low−ISH
|
Human papilloma virus, low risk by ISH, HPV II, HPV LR (6/11)
|
Human papilloma virus probe cocktail; subtypes (6, 11, 42, 43, 44); types 6 and 11 are associated with benign diseases (ie, genital warts)
|
HPV High & Low−ISH
|
Human papilloma virus, high risk and low risk by ISH
|
Human papilloma virus high-and-low-probe cocktails; subtypes (6, 11, 16, 18, 31, 33, 35, 42, 43, 44, 45, 51, 52, 56, 58, 59, 68, 70)
|
IgA
|
Immunoglobulin A, alpha-heavy chain
|
Immunoglobulin A heavy chain
|
IgD
|
Immunoglobulin D, kappa-heavy chain
|
Immunoglobulin D heavy chain
|
IgG
|
Immunoglobulin G, gamma-heavy chain
|
Immunoglobulin G heavy chain
|
IgG4
|
MRQ-44
|
IgG4-related sclerosing disease
|
IgM
|
Immunoglobulin M, mu-heavy chain
|
Immunoglobulin M heavy chain
|
Inhibin
|
Inhibin alpha
|
Sex cord stromal and adrenal cortical tumor; steroid lesion of the ovary
|
Insulin
|
|
Pancreatic endocrine neoplasm
|
JC Virus−ISH
|
JC (PML)
|
Progressive multifocal leukoencephalopathy virus
|
Kappa−IHC
|
Kappa light chain immunoglobulin
|
Immunoglobulin light chain; B-cells and plasma cells
|
Kappa−ISH
|
Kappa by ISH
|
Immunoglobulin light chain; B-cells and plasma cells - RNA
|
KER, PAN
|
Pan-cytokeratin (AE1/AE3/PCK26), NY utilizes Pan-cytokeratin as AE1/AE3
|
Broad-spectrum cytokeratin cocktail
|
Ki-67
|
Ki67
|
Cell proliferation marker
|
Lambda−IHC
|
Lambda light chain immunoglobulin
|
Immunoglobulin light chain; B-cells and plasma cells
|
Lambda−ISH
|
Lambda by ISH
|
Immunoglobulin light chain; B-cells and plasma cells - RNA
|
LH
|
Luteinizing hormone
|
Luteinizing hormone; anterior pituitary
|
Lipase
|
|
Exocrine pancreas; acinar cell tumor
|
Lysozyme (MURA)
|
MURA, muramidase
|
Muramidase; AML; granulocytic sarcoma; histiocytic differentiation
|
Mammaglobin
|
MAM
|
Breast carcinoma; salivary gland lesion and sweat gland neoplasm
|
MART-1
|
NY utilizes clone M2-7C10+M29E3
|
Melanoma-associated marker
|
MBP
|
Myelin basic protein
|
Myelin basic protein; mucin; pancreatic carcinoma vs chronic pancreatitis; colorectal carcinoma; endometrial carcinoma; Barrett's esophagus
|
M-Cell Tryptase
|
Tryptase, mast cell tryptase
|
Mast cells
|
MEL-5
|
|
Melanoma-associated marker
|
Melan-A
|
MART-1, MELAN-AIS, NY utilizes clone A103
|
Melanoma-associated marker; melanocytic lesion and adrenal cortical neoplasm; pecoma
|
Melan-A/Ki-67
|
|
Double stain; useful to distinguish malignant melanoma from benign melanocytic proliferation
|
Mesothelin
|
Meso
|
Mesothelioma
|
MiTF
|
Microphthalmia associated transcription factor, MiTF
|
Malignant melanoma; melanocytic lesion
|
MLH-1
|
hMLH-1
|
DNA mismatch repair protein
|
MOC-31
|
MOC-31, epithelial-related antigen
|
Epithelial differentiation; adenocarcinoma vs mesothelioma
|
MPO
|
Myeloperoxidase, MPX
|
Myeloperoxidase; AML; granulocytic sarcoma
|
MSH-2
|
hMSH2
|
DNA mismatch repair protein
|
MSH-6
|
hMSH6
|
DNA mismatch repair protein
|
MUC1
|
|
Pancreatobiliary and extra-pancreatobiliary non-mucinous adenocarcinoma
|
MUC2
|
|
Colorectal adenocarcinoma and mucinous adenocarcinoma of various sites
|
MUC4
|
|
Epithelial tumor (breast, lung, cervix); pancreatic carcinoma
|
MUC5AC
|
Muc-5AC glycoprotein
|
MUC5AC glycoprotein; distinguish primary mucinous ovarian tumor from colonic carcinoma metastatic to the ovary
|
MUM-1
|
MUM1, IRF4, multiple myeloma 1, PIP
|
Plasma cells; post-germinal B-cells; activated T-cells; Reed-Sternberg cells; DLBCL subset
|
MYO DI
|
MyoD1
|
Rhabdomyosarcoma
|
Myogenin
|
|
Rhabdomyosarcoma
|
Myoglobin
|
|
Rhabdomyosarcoma
|
Myosin Heavy Chain
|
SMM-HC, SMM, myosin smooth muscle
|
Smooth-muscle myosin heavy chain; breast myoepithelial cells
|
Napsin A
|
NAPSA
|
Lung adenocarcinoma
|
NB84a
|
|
Neuroblastoma tumor cells (for bone marrow aspirate and stem cell products, fresh specimen only)
|
NEU-N
|
|
Neuronal differentiation
|
NF
|
Neurofilament
|
Neurofilament; Merkel cells and neural tumor
|
NK1-C3
|
NK1/C3, NKI, melanoma-associated antigen
|
Melanoma-associated marker; melanocytic lesion and neurothekeoma
|
NPM
|
Nucleophosmin
|
Nucleophosmin; nucleophosmin mutations in AML
|
NSE
|
Neuron specific enolase
|
Neuron-specific enolase; present in neurons and neuroendocrine cells (central and peripheral)
|
OCT-2
|
|
B-cell lymphocyte transcription factor; B-cells
|
OCT-3/4
|
|
Testicular germ cell tumor, in particular seminoma and embryonal carcinoma
|
OSCAR
|
Anti-cytokeratin (OSCAR)
|
Broad-spectrum cytokeratin; epithelial lesion
|
p16
|
p16, P16INK4A, MTS1, CDKN2
|
HPV-associated dysplasia/carcinoma (CINtec® p16INK4a)
|
p21
|
p21, P21waf1, cip1, Sdi1, Pic1
|
Tumor suppressor gene
|
p27/Kip1
|
p27, p27Kip1
|
Cyclin-dependent kinase inhibitor
|
p53
|
p53
|
Mutated tumor suppressor gene
|
p57
|
KIP2
|
Molar vs non-molar gestation; distinguish complete hydatidiform mole (CHM) from partial hydatidiform mole (PHM) and hydropic villi
|
p63
|
p63
|
Prostatic basal cells; breast myoepithelial cells; squamous cell carcinoma
|
p120
|
p120 catenin
|
Ductal vs lobular breast lesion; lobular breast carcinoma
|
P504S
|
p504S, AMACR, racemase
|
Prostatic carcinoma and high-grade PIN; subset of renal cell carcinoma
|
Pan Melanoma
|
NY/LA utilizes (HMB-45, MART-1, & Tyrosinase); IRV utilizes (MART-1, S100, & Tyrosinase)
|
Melanoma and melanocytic lesion; pecoma
|
PANC.POLY
|
Pancreatic polypeptide, PP
|
Pancreatic islet-cell tumor subset
|
Parvovirus B19
|
Parvovirus B19, PVB19
|
Parvovirus
|
PAX-2
|
|
Renal cell carcinoma
|
PAX-5
|
PAX-5, Pan B-cell
|
B-cell transcription factor; B-cells; Reed-Sternberg cells; subset of carcinoma including small-cell carcinoma
|
PAX-5/CD43
|
|
Double stain; useful for the identification of CD43- coexpressing B-cell lymphoma
|
PAX-5/CD5
|
|
Double stain; useful for the identification of CD5- coexpressing B-cell lymphoma
|
PAX-8
|
|
Renal cell carcinoma
|
PC (P. carinii)
|
Pneumocystis carinii, P. carinii, PCP, PC
|
Pneumocystis carinii
|
PD1
|
|
Angio immunoblastic T-cell lymphoma (AITL); germinal center T-cells
|
Perforin
|
|
Lymphomas of cytotoxic or NK derivation
|
PGP 9.5
|
Protein gene product 9.5
|
Protein gene product 9.5; neuroendocrine tumor
|
PLAP
|
Placental alkaline phosphatase
|
Placental alkaline phosphatase; germ cell tumor; trophoblastic disease and subset of adenocarcinoma
|
PMS-2
|
|
DNA mismatch repair protein
|
PR
|
Progesterone receptor, PgR
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Progesterone receptor; predictive of endocrine therapy response in breast carcinoma; lower female genital tract carcinoma; endometrial stromal neoplasm; soft tissue lesion subset
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Prolactin
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PL, PRO
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Anterior pituitary hormone
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PSA
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Prostate specific antigen
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Prostate-specific antigen; primary and metastatic prostatic neoplasm
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PSAP
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HPAP, PACP, prostatic acid phosphatase
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Prostatic acid phosphatase; primary and metastatic neoplasm; carcinoid tumor subset
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PSMA
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PSM, FOLH, GCP2
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Prostate adenocarcinoma
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PTEN
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MMAC, TEP1
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Cowden syndrome; carcinoma of the bladder, breast, endometrium, head and neck, kidney, lung, prostate, stomach, and thyroid; glioblastoma; melanoma
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PTH
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Parathyroid hormone
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Parathyroid hormone; parathyroid neoplasm
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PTS
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Prostate triple stain, TriView™ Prostate
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Prostate triple stain (P504S, p63, CK903); useful for the diagnosis of PIN/adenosis vs prostate carcinoma
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RB
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Retinoblastoma
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Retinoblastoma gene protein; retinoblastoma
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RCC (PNRA)
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RCC, PNRA, renal cell carcinoma antigen, gp200
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Renal cell carcinoma
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S6
|
s6
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Correlates with an increase in translation, particularly mRNAs with an oligopyrimidine tract
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S100
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S-100
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Neural tumor; melanoma; chondrocytes; epithelial neoplasm subset
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Serotonin
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SERO
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Carcinoid; pancreatic endocrine neoplasm
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Somatostatin
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SOMA
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Somatostatin; islet cell tumor; carcinoid; pancreatic endocrine neoplasm
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Surfactant (SP-A)
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SP-A, surfactant protein A, surfactant apoprotein A (SP-A), PE10
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Surfactant protein A; lung adenocarcinoma
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Synaptophysin
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SYN
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Neural and neuroendocrine-derived tumor
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Synuclein
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Alpha-synuclein
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Neurodegenerative diseases (synucleinopathies); Parkinson's disease
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TAU
|
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Neurofibrillary tangles; Lewy bodies
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TCL-1
|
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Ewing sarcoma/PNET; blastic plasmacytoid dendritic cell neoplasm (BPDCN)
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TCR β
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TCR beta F1
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Alpha-beta T-cells
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TdT
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Terminal deoxynucleotidyl transferase
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Terminal deoxynucleotidyl transferase; cortical thymocytes; B-ALL; T-ALL
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Thrombomodulin
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CD141, TM, CD141, Thrombo
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Mesothelial cells; mesothelioma; lymphatic and vascular tumor
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Thyroglobulin
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THYRO, TGB
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Follicular and papillary carcinoma of the thyroid
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TIA-1
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T-cell intracytoplasmic antigen
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T-cell intracytoplasmic antigen; cytotoxic T-cell subset
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TOXO
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Toxoplasma gondii, toxoplasmosis
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Toxoplasmosis
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TRAP
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Tartrate-resistant acid phosphatase
|
Tartrate-resistant acid phosphatase; hairy cell leukemia
|
TriView™ Breast
|
Breast triple stain, breast microinvasion, CK5/p63/LMW
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Breast triple stain (CK5/p63/LMW); useful to differentiate DCIS from microinvasive breast carcinoma; differentiate radial scar from infiltrating carcinoma
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TriView™ Prostate
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PTS, PIN4, PIN 4 cocktail
|
Prostate triple stain (P504S, p63, CK903); useful for the diagnosis of PIN/adenosis vs prostate carcinoma
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Trypsin
|
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Exocrine pancreas; acinar cell tumor
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TS
|
Thymidylate synthase
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Thymidylate synthase; prognostic and predictive indicator for 5-FU-based chemotherapy in colorectal carcinoma
|
TSH
|
Thyroid stimulating hormone
|
Thyroid-stimulating hormone; anterior pituitary
|
TTF-1
|
Thyroid transcription factor-1, TTF
|
Thyroid transcription factor-1; lung and thyroid carcinoma; subset of small cell carcinoma
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Tyrosinase
|
Tyro
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Malignant melanoma; melanocytic lesion
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Ubiquitin
|
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Neurofibrillary tangles; Lewy bodies
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Uroplakin
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Uroplakin III, UPIII
|
Urinary tract transitional cell carcinoma (primary and metastatic)
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VEGF
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Vascular endothelial growth factor, vascular permeability factor (VPF), VEGFR
|
Vascular endothelial growth factor; stimulates endothelial cell proliferation; induces microvessel permeability; prognostic indicator
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Villin
|
|
Differentiate gastrointestinal adenocarcinoma, neuroendocrine carcinoma, and ovarian adenocarcinoma from other adenocarcinoma; label Merkel cells of the skin
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Vimentin (VIM)
|
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Mesenchymal neoplasms; malignant melanoma and subsets of carcinoma and lymphoma
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VIP
|
Vasoactive intestinal polypeptide
|
Vasoactive intestinal polypeptide; pancreatic endocrine neoplasm
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VZV
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Varicella-Zoster virus
|
Varicella-Zoster virus
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WT1 (M) N-Terminus
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Wilms' tumor protein
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Wilms' tumor protein; mesothelial cells; malignant mesothelioma; ovarian adenocarcinoma; sex cord stromal tumor of the ovary; endometrioid stromal neoplasm
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WT1 (P) C-Terminus
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Wilms' tumor protein
|
Wilms' tumor protein carboxyl terminal; desmoplastic small round cell tumor
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ZAP-70
|
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T-cells; CLL/SLL prognosis
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