Microarray-Tumor Reveal® FFPE

CPT: 81229
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Synonyms

  • aCGH
  • CGH
  • CMA
  • Microarray Oncology
  • Reveal® SNP Array
  • WGA

Special Instructions

Pertinent medical findings should accompany the test request form. If prior FISH analysis has been performed, include copy of report. Please direct questions to genetic customer service at 800-345-4363.


Expected Turnaround Time

12 - 15 days


Related Documents


Specimen Requirements


Specimen

Formalin fixed paraffin embedded (FFPE) tissue


Volume

One paraffin block or ten 10-micron thick section slides


Minimum Volume

Sufficient sample to obtain enough DNA to run microarray


Container

Paraffin block transport pouch


Collection

FFPE specimen should be fixed in 10% neutral-buffered formalin or formaldehyde.


Storage Instructions

Room temperature


Causes for Rejection

Improperly embedded preparation; decalcified bone or bone core


Test Details


Use

This test will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.


Limitations

This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy. Genotypes in some formalin-fixed tissues are unable to be determined, allowing only genomic dosage to be determined.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.


Methodology

SNP Microarray analysis is performed using the Oncoscan® FFPE platform, which uses more than 220,000 SNP probes with a median spacing of 5.0 kb, within the majority of genes.


References

Nauen D, Haley L, Lin MT, et al. Molecular analysis of pediatric oligodendrogliomas highlights genetic differences with adult counterparts and other pediatric gliomas. Brain Pathol. 2016 Mar;26(2):206-214.26206478

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
512014 Reveal(R) Tumor Paraffin 512006 Specimen Type 31208-2
512014 Reveal(R) Tumor Paraffin 512007 # of Genotyping Targets N/A
512014 Reveal(R) Tumor Paraffin 512008 Array Type N/A
512014 Reveal(R) Tumor Paraffin 512009 Diagnosis 48000-4
512014 Reveal(R) Tumor Paraffin 512010 Interpretation 62365-2
512014 Reveal(R) Tumor Paraffin 512011 Director Review 48672-0
512014 Reveal(R) Tumor Paraffin 512123 PDF 51967-8

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